26/03/2024

List of ANSES toxicity reference values (TRVs)

The Agency entrusted TRV validation to the Expert Committee (CES) on "Health reference values ". Accordingly, toxicity reference values have already been established  for the following substances (substances or mixtures).

See our article on toxicity reference values (TRVs) 

ChemicalPublication yearSort of TRVTRVInternal TRV
Substances

1,2 dichloroethane

(CAS 107-06-2)

2009

Long-term TRV without threshold

Inhalation route 

 

3.4.10-3 (mg.m-3)-1

 

/

1,3-butadiène

(CAS 106-99-0)

2022

Long-term TRV (with threshold)

Inhalation route

2 µg.m-3/

Long-term TRV without threshold

Inhalation route 

2,43.10-7 (µg.m-3)-1/

2-chloroaniline

(CAS 95-51-2)

2018

Short-term TRV

Oral route

73 µg.kg p.c.-1.d-1/
2018

Short-term TRV

Inhalation route

256 µg.m-3
2018

Medium-termTRV

Oral route

16 µg.kg p.c.-1.d-1

2018

Medium-termTRV

Inhalation route

55 µg.m-3
2018

Long-term TRV (with threshold)

Oral route

5 µg.kg p.c.-1.d-1
2018

Long-term TRV (with threshold)

Inhalation route

18 µg.m-3

2-ethoxyethanol

(CAS 110-80-5)

2009

Long-term TRV (with threshold)

Inhalation route

0.07 mg.m-3

/

3-chloroaniline

(CAS 108-42-9)

2018

Short-term TRV

Oral route

11 µg.kg p.c.-1.d-1/
2018

Short-term TRV

Inhalation route

39 µg.m-3
2018

Medium-term TRV

Oral route

5 µg.kg p.c.-1.d-1
2018

Medium-term TRV

Inhalation route

18 µg.m-3
2018

Long-term TRV (with threshold)

Oral route

1 µg.kg p.c.-1.d-1
2018

Long-term TRV (with threshold)

Inhalation route

4 µg.m-3

4-chloroaniline

(CAS 106-47-8)

2018

Medium-term TRV

Oral route

5 µg.kg p.c.-1.d-1/
2018

Medium-term TRV

Inhalation route

18 µg.m-3
2018

Long-term TRV (with threshold)

Oral route

1 µg.kg p.c.-1.d-1
2018

Long-term TRV (with threshold)

Inhalation route

4 µg.m-3

4-Vinyl-1-cyclohexene

(CAS 100-40-3)

2015

Long-term TRV (with threshold)

Oral route

0.32 mg .kg.pc-1.d-1/
2015

Long-term TRV (with threshold)

Inhalation route

2.7 mg.m-3
2015

Long-term TRV without threshold

Oral route

1,3.10-5 (µg.kg p.c.-1.d-1)-1
2015

Long-term TRV without threshold

Inhalation route

3.8.10-6 (µg.m-3)-1

Acrolein

(CAS 107-02-8)

2022

(in French only)

Short-termTRV

Inhalation route

6.9 µg.m-3/

Medium-term TRV

Inhalation route

0.44 µg.m-3

Long-term TRV (with threshold)

Inhalation route

0.2 µg.m-3

Long-term TRV without threshold

Inhalation route

No TRV

Ammonia

(CAS 7664-41-7)

2017

Short-term TRV

Inhalation route

5.9 mg.m-3/

Medium-term TRV

Inhalation route

0.5 mg.m-3

Long-term TRV (with threshold)

Inhalation route

0.5 mg.m-3

Benzene

(CAS 71-43-2)

2013

Long-term TRV without threshold

Inhalation route

2.6.10-5 (µg.m-3)-1

/

bis(2-ethylhexyl) phthalate

(DEHP)

(CAS 117-81-7)

2012

Long-term TRV (with threshold)

Oral route

0.05 mg.kg-1.d-1

/

Butyl benzyl phthalate (BBP)

(CAS 85-68-7)

2008

Medium-term TRV

Oral route

0.5 mg.kg-1.d-1

/

Bromochloroacetic acid

(CAS 5589-96-8)

2023

(In French only)

Long-term TRV without threshold

Oral route 2023

0.16 (mg.kg-1.d-1)-1/

Bromodichloroacetic acid

(CAS 71133-14-7)

2023

(In French only)

Long-term TRV without threshold

Oral route 2023

0.25 (mg.kg-1.d-1)-1/

Cadmium and cadmium compounds

(CAS 7440-43-9, 10108-6-2,

1306-19-0, 10124-36-4,

1306-23-6, 10325-94-7)

2017

(in French only)

Long-term TRV (with threshold)

Oral route

0.35 µg.kg-1.d-1 0,5 µg/g creat 

2012

Long-term TRV (with threshold)

Inhalation route 

0.45 µg.m-3

Long-term TRV (with threshold)

Inhalation route

0.3 µg.m-3

Carbon tetrachloride

(CAS 56-23-5)

2017

Long-term TRV without threshold

Inhalation route

0.11 mg.m-3

/

Chloral hydrate

(CAS 302-17-0)

2010

Long-term TRV (with threshold)

Oral route

28 µg.kg-1.d-1

/

Chlordecone

(CAS 143-50-0)

2021

(in French only)

Long-term TRV (with threshold)

Oral route

0.17 µg.kg-1.d-10,40 µg/L plasma

Chloroform

(CAS 67-66-3)

2008

Long-term TRV (with threshold)

Inhalation route

63 µg.m-3

/

Cylindrospermopsin

(CAS 143 545-90-8)

2019

Medium-term TRV

Oral route

0.14 µg.kg-1.d-1/

Decamethylcyclopentasiloxane (D5)

(CAS 541-02-6)

2017

Long-term TRV (with threshold)

Inhalation route

6.4 mg.m-3

/

Dibromoacetic acid

(CAS 631-64-1)

2010

Chronic TRV

Oral route

30 µg.kg-1.d-1

/

2023

(In French only)

Long-term TRV without threshold

Oral route

0.048 (mg.kg-1.d-1)-1 

Dibromochloroacetic acid

(CAS 5278-95-5)

2023

(In French only)

Long-term TRV

Oral route

No TRV/

Dibutyl phthalate (DBP)

(CAS 84-74-2)

2008

Medium-term TRV

Oral route

0,002 mg.kg-1.d-1

/

 Diisobutylene (DIB)

(CAS 25167-70-8)

2015

Long-term TRV (with threshold)

Oral route

0.8 mg.kg pc-1.d-1

/

2015

Long-term TRV (with threshold)

Inhalation route

3 mg.m-3

Diisopropyl ether (DIPE)

(CAS 108-20-3)

 

2015

Long-term TRV (with threshold)

Oral route

4 mg.kg pc-1.d-1

/

2015

Long-term TRV (with threshold)

Inhalation route

14.5 mg.m-3

2015

Developmental TRV

Oral route

2 mg.kg pc-1.d-1

2015

Developmental TRV

Inhalation route

7.2 mg.m-3

2015

Long-term TRV without threshold

Oral route

7.8.10-6 (µg.kg p.c.-1.d-1)-1

2015

Long-term TRV without threshold

Inhalation route

2.2.10-6 (µg.m-3)-1

Dichloroacetic acid

(CAS 79-43-6)

2009

Short-term TRV

Oral route

260 µg.kg-1.d-1

/

Long-term TRV (with threshold)

Oral route

840 µg.kg-1.d-1

2023

(In French only)

Long-term TRV without threshold

Oral route

0,048 (mg.kg-1.d-1)-1/

Diisobutyl phthalate (DIBP)

(CAS 84-69-5)

2017

Short-term TRV (reprotoxic)

Oral route

0.002 mg.kg-1.d-1

/

Diisooctyl phthalate (DIOP)

(CAS 27554-26-3)

2017

Short-term TRV (reprotoxic)

Oral route

0.004 mg.kg-1.d-1

/

Dimethyl phthalate

(CAS 131-22-3)

2015

 

No TRV

/

Di-n-octyl phthalate (DnOP)

(CAS 117-84-0)

2017

 

No TRV

/

Ethyl acetate

(CAS 141-78-9)

2015

Long-term TRV (with threshold)

Inhalation route

6.4 mg.m-3

/

Ethylbenzene

(CAS 100-41-1)

2016

Short-term TRV

Inhalation route

22 mg.m-3

/

Medium-term TRV

Inhalation route

4.3 mg.m-3

Long-term TRV (with threshold)

Inhalation route

1.5 mg.m-3

Formaldehyde

(CAS 50-00-0)

2017

Short-term TRV

Inhalation route

123 µg.m-3

/

Long-term TRV (with threshold)

Inhalation route

123 µg.m-3

Lead

(CAS 7439-92-1)

2012

Blood lead level

 

15 µg.L-1 blood

Linuron

(CAS 330-55-2)

2008

Medium-term TRV

Oral route

0.05 mg.kg-1.d-1

/

Methyl methacrylate

(CAS 80-62-6)

2017

Long-term TRV (with threshold)

Inhalation route

0.7 mg.m-3

/

Microcystin-LR

(CAS 101043-37-02)

2019

Medium-term TRV

Oral route

1 ng.kg-1.d-1/

Monochloroacetic acid

(CAS 79-11-8)

2023

(In French only)

Long-term TRV (with threshold)

Oral route
10 µg.kg-1.d-1 

n-butyl acetate

(CAS 123-86-4)

2017

Long-term TRV (with threshold)

Inhalation route

2 mg.m-3

/

N-hexane

(CAS 110-54-3)

2013

Long-term TRV (with threshold)

Inhalation route

3 mg.m-3

/

m-nitrochlorobenzene

(CAS 121-73-3)

2009

Long-term TRV without threshold

Inhalation and oral route

No TRV

/

N-nitrosomorpholine

(CAS 59-89-2)

2012

Long-term TRV without threshold

Oral route

4 (mg.kg p.c.-1.d-1)-1

/

Naphthalene

(CAS 91-20-3)

2013

Long-term TRV (with threshold)

Inhalation route

37 µg.m-3

/

Long-term TRV without threshold

Inhalation route

5.6.10-3 (mg.m-3)-1

o- nitrochlorobenzene

(CAS 88-73-3)

2009

Long-term TRV (with threshold)

Oral route

80 µg.kg-1.d-1

/

2009

Long-term TRV without threshold

Oral route

6.10-5 (µg.kg-1.d-1)-1

p-nitrochlorobenzene

(CAS 100-00-5)

2009

Long-term TRV (with threshold)

Oral route

34 µg.kg-1.d-1

/

2009

Long-term TRV without threshold

Oral route

5.10-5 (µg.kg-1.d-1)-1

Nonylphenol - branched

(CAS 90481-04-2 84852-15-3)

2009

Medium-term TRV

Oral route

0.03 mg.kg-1.d-1

/

Nonylphenol - linear

(CAS 25154-52-3 / 104-40-5)

2009

Medium-term TRV

Oral route

0.03 mg.kg-1.d-1

/

Octamethylcyclotetrasiloxane

(CAS S 556-67-2)

2017

Long-term TRV (with threshold)

Inhalation route

183 mg.m-3

/

Palytoxin

(CAS 77734-91-9)

2023

(in French only)

Short-term TRV

Oral route

0.08 µg.kg-1.d-1/

No short- and medium-term TRV

Respiratory and dermal route

 /

Particulate matter in ambient air PM2.5

2023

(in French only)

Long-term TRV without threshold

Inhalation route

1.28.10-2 (µg.m-3)-1

To refine, use the parametric function

/

Particulate matter in ambient air PM10

2023

(in French only)

Long-term TRV without threshold 

Inhalation route

Conversion of PM10 exposure concentration to PM2.5 concentration, then use the long-term TRV of PM2.5/

Perchlorates ions

(CAS 14797-73-0) 

2022

Long-term TRV (with threshold)

Oral route

1.5 µg.kg-1.d-1/

Perchloroethylene

(CAS 127-18-4)

2018

Short-term TRV

Inhalation route

1.38 mg.m-3

/

Medium-term TRV

Inhalation route

0.4 mg.m-3

Long-term TRV (with threshold)

Inhalation route

0.4 mg.m-3

Long-term TRV without threshold

Inhalation route

2.6.10-7 (µg.m-3)-1

 

Perfluorobutanesulfonic acid

(CAS 375-73-5)

2017

Long-term TRV (with threshold)

Oral route

0.08 mg.kg-1.d-1

/

Perfluorohexanoic acid

(CAS 307-24-4)

2017

Long-term TRV (with threshold)

Oral route

0.32 mg.kg-1.d-1

/

Pinnatoxine G

(CAS 1312711-74-2)

2019

(in French only)

Provisional acute TRV

Oral route

0.13 µg.kg pc-1.j-1/

Saxitoxin

(CAS 35523-89-8)

2020

Acute TRV

Oral route

0.1 µg.kg-1.j-1/

Sec butyl éther

(CAS 6863-58-7)

2015

No TRV

/

Tert-butanol (TBA)

(CAS 75-65-0)

2015

Reprotoxic TRV

Oral route

1.9 mg.kg pc-1.d-1

/

2015

Long-term TRV (with threshold)

Oral route

0.6 mg.kg pc-1.d-1

2015

Long-term TRV (with threshold)

Inhalation route

2.1 mg.m-3

Titanium dioxide

under nanoform (P25)

(CAS 13463-67-7)

2019

Long-term TRV (with threshold)

Inhalation route

0.12 µg.m-3/

Tribromoacetic acid

2023

(in French only)

 

Long-term TRV (with threshold)

Oral route
No TRV/

Trichloroacetic acid

(CAS 76-03-9)

2009

Short-term TRV

Oral route

300 µg.kg-1.d-1

/

2023

(in French only)

Long-term TRV (with threshold)

Oral route

20 µg.kg-1.d-1/

Trichloroethylene

(CAS 79-01-6)

2018

 

Short-term TRV

Inhalation route

No TRV/
2018

 

Medium-term TRV

Inhalation route

3.2mg.m-3
2018

 

Long-term TRV (with threshold)

Inhalation route

3.2 mg.m-3
2018

Long-term TRV without threshold

Inhalation route

10-6 (µg.m-3)-1

Toluene

(CAS 108-88-3)

2017

 

Short-term TRV

Inhalation route

21 mg.m-3

/

Long-term TRV (with threshold)

Inhalation route

19 mg.m-3

Vinyl chloride

(CAS 75-01-4)

2012

Long-term TRV without threshold

Oral route

0.625 (mg.kg-1.d-1)-1

/

2012

Long-term TRV without threshold

Inhalation route

0.0038 (mg.m-3)-1

Sodium valproate

(CAS 1069-66-5)

2021

(in French only)

Reprotoxic TRV

Oral route

0.08 mg.kg-1.d-1/

Reprotoxic TRV

Inhalation route

0.26 mg.m-3

Long-term TRV (with threshold)

Oral route

0.03 mg.kg-1.d-1

Long-term TRV (with threshold)

Inhalation route

0.12 mg.m-3

Xylènes

(xylène technique CAS n°1330-20-7

méta-xylène CAS n°108-38-3

ortho-xylène CAS n°95-47-6

para-xylène CAS n°106-42-3)

2020

Short-term TRV

Inhalation route

8.7 mg.m-3/
2020

Long-term TRV (with threshold)

Inhalation route

0.1 mg.m-3
Mixtures

BTEX mixture

(benzene, toluene, ethylbenzene, xylenes) 

2022

Toxicological value based on the common effect considered for

the different chemicals of the mixture (MTV)

Benzene : MTVneurotoxicy = 0.065 mg.m-3

Toluene : MTVneurotoxicy = 19 mg.m-3

Ethylbenzene : MTVneurotoxicy = 6 mg.m-3

Xylenes : MTVneurotoxicy = 0.1 mg.m-3

 
 Update date : March 2024