List of ANSES toxicity reference values (TRVs)

The Agency entrusted TRV validation to the Expert Committee (CES) on "Health reference values ". Accordingly, toxicity reference values have already been established for the following substances (substances or mixtures).

> See our article on toxicity reference values (TRVs)

Chemical	Publication year	Sort of TRV	TRV	Internal TRV
Substances
1,2 dichloroethane (CAS 107-06-2)	2009	Carcinogen TRV Inhalation route	3,4.10^-3 (mg.m^-3)^-1	/
1,3-butadiène (CAS 106-99-0)	2022	Chronic TRV Inhalation route	2 µg.m^-3	/
1,3-butadiène (CAS 106-99-0)	2022	Carcinogen TRV Inhalation route	2,43.10^-7 (µg.m^-3)^-1	/
2-chloroaniline (CAS 95-51-2)	2018	Acute TRV Oral route	73 µg.kg p.c.^-1.d^-1	/
	2018	Acute TRV Inhalation route	256 µg.m^-3
	2018	Subchronic TRV Oral route	16 µg.kg p.c.^-1.d^-1
	2018	Subchronic TRV Inhalation route	55 µg.m^-3
	2018	Chronic TRV Oral route	5 µg.kg p.c.^-1.d^-1
	2018	Chronic TRV Inhalation route	18 µg.m^-3
2-ethoxyethanol (CAS 110-80-5)	2009	Chronic TRV Inhalation route	0,07 mg.m^-3	/
3-chloroaniline (CAS 108-42-9)	2018	Acute TRV Oral route	11 µg.kg p.c^.-1.d^-1	/
	2018	Acute TRV Inhalation route	39 µg.m^-3
	2018	Subchronic TRV Oral route	5 µg.kg p.c.^-1.d^-1
	2018	Subchronic TRV Inhalation route	18 µg.m^-3
	2018	Chronic TRV Oral route	1 µg.kg p.c.^-1.d^-1
	2018	Chronic TRV Inhalation route	4 µg.m^-3
4-chloroaniline (CAS 106-47-8)	2018	Subchronic TRV Oral route	5 µg.kg p.c.^-1.d^-1	/
	2018	Subchronic TRV Inhalation route	18µg.m^-3
	2018	Chronic TRV Oral route	1 µg.kg p.c.^-1.d^-1
	2018	Chronic TRV Inhalation route	4 µg.m^-3
4-Vinyl-1-cyclohexene (CAS 100-40-3)	2015	Chronic TRV Oral route	0,32 mg .kg.pc^-1.d^-1	/
	2015	Chronic TRV Inhalation route	2,7 mg.m^-3
	2015	Carcinogen TRV Oral route	1,3.10^-5 (µg.kg p.c.^-1.d^-1)^-1
	2015	Carcinogen TRV Inhalation route	3,8.10^-6 (µg.m^-3)^-1
Acrolein (CAS 107-02-8) (in French only)	2022	Acute TRV Inhalation route	6,9 µg.m^-3	/
		Subchronic TRV Inhalation route	0,44 µg.m^-3
		Chronic TRV Inhalation route	0,2 µg.m^-3
		Carcinogen TRV Inhalation route	No TRV
Ammonia (CAS 7664-41-7)	2017	Acute TRV Inhalation route	5,9 mg.m^-3	/
		Subchronic TRV Inhalation route	0,5 mg.m^-3
		Chronic TRV Inhalation route	0,5 mg.m^-3
Benzene (CAS 71-43-2)	2013	Carcinogen TRV Inhalation route	2,6.10^-5 (µg.m^-3)^-1	/
bis(2-ethylhexyl) phthalate (DEHP) (CAS 117-81-7)	2012	Chronic TRV Oral route	0,05 mg.kg^-1.d^-1	/
Butyl benzyl phthalate (BBP) (CAS 85-68-7)	2008	Subchronic TRV Oral route	0,5 mg.kg^-1.d^-1	/
Cadmium and cadmium compounds (CAS 7440-43-9, 10108-6-2, 1306-19-0, 10124-36-4, 1306-23-6, 10325-94-7)	2017 (in French)	Chronic TRV Oral route	0,35 µg.kg-1.d-1	0,5 µg/g creat
	2012	Chronic TRV Inhalation route	0,45 µg.m^-3
	2012	Carcinogen TRV Inhalation route	0,3 µg.m^-3
Carbon tetrachloride (CAS 56-23-5)	2017	Carcinogen TRV Inhalation route	0,11 mg.m^-3	/
Chloral hydrate (CAS 302-17-0)	2010	Chronic TRV Oral route	28 µg.kg^-1.d^-1	/
Chlordecone (CAS 143-50-0) (in French)	2021	Chronic TRV Oral route	0,17 µg.kg^-1.d^-1	0,40 µg/L plasma
Chloroform (CAS 67-66-3)	2008	Chronic TRV Inhalation route	63 µg.m^-3	/
Cylindrospermopsin (CAS 143 545-90-8)	2019	Subchronic TRV Oral route	0,14 µg.kg^-1.d^-1	/
Decamethylcyclopentasiloxane (D5) (CAS 541-02-6)	2017	Chronic TRV	6,4 mg.m^-3	/
Dibromoacetic acid (CAS 631-64-1)	2010	Chronic TRV Oral route	30 µg.kg^-1.d^-1	/
Dibutyl phthalate (DBP) (CAS 84-74-2)	2008	Subchronic TRV Oral route	0,002 mg.kg^-1.d^-1	/
Diisobutylene (DIB) (CAS 25167-70-8)	2015	Chronic TRV Oral route	0,8 mg.kg pc^-1.d^-1	/
Diisobutylene (DIB) (CAS 25167-70-8)	2015	Chronic TRV Inhalation route	3 mg.m^-3	/
Diisopropyl ether (DIPE) (CAS 108-20-3)	2015	Chronic TRV Oral route	4 mg.kg pc^-1.d^-1	/
	2015	Chronic TRV Inhalation route	14,5 mg.m^-3
	2015	Developmental TRV Oral route	2 mg.kg pc^-1.d^-1
	2015	Developmental TRV Inhalation	7,2 mg.m^-3
	2015	Carcinogen TRV Oral route	7,8.10^-6 (µg.kg p.c.^-1.d^-1)^-1
	2015	Carcinogen TRV Inhalation route	2,2.10^-6(µg.m^-3)^-1
Dichloroacetic acid (CAS 79-43-6)	2009	Acute TRV Oral route	260 µg.kg^-1.d^-1	/
Dichloroacetic acid (CAS 79-43-6)	2009	Chronic TRV Oral route	840 µg.kg^-1.d^-1	/
Diisobutyl phthalate (DIBP) (CAS 84-69-5)	2017	Acute TRV (reprotoxic) Oral route	0,002 mg.kg^-1.d^-1	/
Diisooctyl phthalate (DIOP) (CAS 27554-26-3)	2017	Acute TRV (reprotoxic) Oral route	0,004 mg.kg-1.d-1	/
Dimethyl phthalate (CAS 131-22-3)	2015		No TRV	/
Di-n-octyl phthalate (DnOP) (CAS 117-84-0)	2017		No TRV	/
Ethyl acetate (CAS 141-78-9)	2015	Chronic TRV Inhalation route	6,4 mg.m^-3	/
Ethylbenzene (CAS 100-41-1)	2016	Acute TRV Inhalation route	22 mg.m^-3	/
		Subchronic TRV Inhalation route	4,3 mg.m^-3
		Chronic TRV Inhalation route	1,5 mg.m^-3
Formaldehyde (CAS 50-00-0)	2017	Acute TRV Inhalation route	123 µg.m^-3	/
Formaldehyde (CAS 50-00-0)	2017	Chronic TRV Inhalation route	123 µg.m^-3	/
Lead (CAS 7439-92-1)	2012	Blood lead level		15 µg.L^-1 blood
Linuron (CAS 330-55-2)	2008	Subchronic TRV Oral route	0,05 mg.kg^-1.d^-1	/
Methyl methacrylate (CAS 80-62-6)	2017	Chronic TRV Inhalation route	0,7 mg.m^-3	/
Microcystin-LR (CAS 101043-37-02)	2019	Subchronic TRV Oral route	1 ng.kg^-1.d^-1	/
n-butyl acetate (CAS 123-86-4)	2017	Chronic TRV Inhalation route	2 mg.m^-3	/
N-hexane (CAS 110-54-3)	2013	Chronic TRV Inhalation route	3 mg.m^-3	/
m-nitrochlorobenzene (CAS 121-73-3)	2009	Carcinogen TRV Inhalation and oral route	No TRV	/
N-nitrosomorpholine (CAS 59-89-2)	2012	Carcinogen TRV Oral route	4 (mg.kg p.c.^-1.d^-1)^-1	/
Naphthalene (CAS 91-20-3)	2013	Chronic TRV Inhalation route	37 µg.m^-3	/
Naphthalene (CAS 91-20-3)	2013	Carcinogen TRV Inhalation route	5,6.10^-3 (mg.m^-3)^-1	/
o- nitrochlorobenzene (CAS 88-73-3)	2009	Chronic route Oral route	80 µg.kg^-1.d^-1	/
o- nitrochlorobenzene (CAS 88-73-3)	2009	Carcinogen TRV Oral route	6.10^-5 (µg.kg^-1.d^-1)^-1	/
p-nitrochlorobenzene (CAS 100-00-5)	2009	Chronic TRV Oral route	34 µg.kg^-1.d^-1	/
p-nitrochlorobenzene (CAS 100-00-5)	2009	Carcinogen TRV Oral route	5.10^-5 (µg.kg^-1.d^-1)^-1	/
Nonylphenol - branched (CAS 90481-04-2 84852-15-3)	2009	Subchronic TRV Oral route	0,03 mg.kg^-1.d^-1	/
Nonylphenol - linear (CAS 25154-52-3 / 104-40-5)	2009	Subchronic TRV Oral route	0,03 mg.kg^-1.d^-1	/
Octamethylcyclotetrasiloxane (CAS S 556-67-2)	2017	Chronic TRV Inhalation route	183 mg.m^-3	/
Perchlorates ions (CAS 14797-73-0)	2022	Chronic TRV Oral route	1.5 µg.kg^-1.d^-1	/
Perchloroethylene (CAS 127-18-4)	2018	Acute TRV Inhalation route	1,38 mg.m^-3	/
		Subchronic TRV Inhalation route	0,4 mg.m^-3
		Chronic TRV Inhalation route	0,4 mg.m^-3
		Carcinogen TRV Inhalation route	2,6.10^-7(µg.m^-3)^-1
Perfluorobutanesulfonic acid (CAS 375-73-5)	2017	Chronic TRV Oral route	0,08 mg.kg^-1.d^-1	/
Perfluorohexanoic acid (CAS 307-24-4)	2017	Chronic TRV Oral route	0,32 mg.kg^-1.d^-1	/
Pinnatoxine G (CAS 1312711-74-2) (in French only)	2019	Provisional acute TRV Oral route	0.13 µg.kg pc^-1.j^-1	/
Saxitoxin (CAS 35523-89-8)	2020	Acute TRV Oral route	0,1 µg.kg^-1.j^-1	/
Sec butyl éther (CAS 6863-58-7)	2015	No TRV		/
Tert-butanol (TBA) (CAS 75-65-0)	2015	TRV toxic to reproduction Oral route	1,9 mg.kg pc^-1.d^-1	/
	2015	Chronic TRV Oral route	0,6 mg.kg pc^-1.d^-1
	2015	Chronic TRV Inhalation route	2,1 mg.m^-3
Titanium dioxide under nanoform (P25) (CAS 13463-67-7)	2019	Chronic TRV Inhalation	0,12 µg.m^-3	/
Trichloroacetic acid (CAS 76-03-9)	2009	Acute TRV Oral route	300 µg.kg^-1.d^-1	/
Trichloroethylene (CAS 79-01-6)	2018	Acute TRV Inhalation route	No TRV	/
	2018	Subchronic TRV Inhalation route	3,2mg.m^-3
	2018	Chronic TRV Inhalation route	3,2 mg.m^-3
	2018	Carcinogen TRV Inhalation route	10^-6 (µg.m^-3)^-1
Toluene (CAS 108-88-3)	2017	Acute TRV Inhalation route	21 mg.m^-3	/
Toluene (CAS 108-88-3)	2017	Chronic TRV Inhalation route	19 mg.m^-3	/
Vinyl chloride (CAS 75-01-4)	2012	Carcinogen TRV Oral route	0,625 (mg.kg^-1.d^-1)^-1	/
Vinyl chloride (CAS 75-01-4)	2012	Carcinogen TRV Inhalation route	0,0038 (mg.m^-3)^-1	/
Sodium valproate (CAS 1069-66-5) (in French)	2021	Reprotoxic TRV Oral route	0,08 mg.kg^-1.d^-1	/
		Reprotoxic TRV Inhalation route	0,26 mg.m^-3
		Chronic TRV Oral route	0,03 mg.kg^-1.d^-1
		Chronic TRV Inhalation route	0,12 mg.m^-3
Xylènes (xylène technique CAS n°1330-20-7 méta-xylène CAS n°108-38-3 ortho-xylène CAS n°95-47-6 para-xylène CAS n°106-42-3)	2020	Acute TRV Inhalation route	8,7 mg.m^-3	/
	2020	Chronic TRV Inhalation route	0,1 mg.m^-3	/

Update date : December 2022

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